Fast disintegrating tablets offer an advantage for populations who have difficulty in swallowing. Many fast-disintegrating tablets (FDTs) still face problems of low mechanical strength, poor mouth-feel and higher disintegration times. The purpose of this study is to assess the suitability of spray dried excipient base over direct compression base in the formulation of ODTs of Atenolol (Sparingly aqueous solubility). Spray dried excipient base was prepared using Labultima spray drier. Super disintegrants (such as Ac-Di-Sol, sodium starch glycolate, Kollidon CL), diluent (mannitol) alongwith sweetening agent (aspartame) were used in the formulation of tablets. The tablets were evaluated for angle of repose, hardness, friability, water absorption ratio, disintegration time (DT) and in vitro drug release. Using the same excipients, the tablets were prepared by direct compression and were evaluated in the similar way. Particle size and morphology were compared for both excipient bases. The angle of repose was reduced in spray dried excipient base rather than directly compression base which might be due to increased sphericity of particles indicating that powder is free flowing. The disintegration time and in vitro drug release time were reduced in tablets prepared from spray dried excipient base rather than tablets prepared from direct compression base. Maximum drug release and minimum DT were observed with Kollidon CL excipient base as compared to tablets prepared by direct compression, showing the superiority of the spray dried excipient base technique over direct compression technique.
Loading....